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Speaker ~ Prof Dra Silvana Marques de Araújo

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admin 發表於 2015-6-6 19:49:48 | 顯示全部樓層 |閱讀模式
DAY 2 – 6 June2014 1400-1520
Lab-based research實驗室為本的研究
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Prof Dra SilvanaMarques de Araújo,
Brazil.  Exploring the model of murine infection byTrypanosoma cruzi to investigate treatment with highly diluted drugs: theinfluence of Lycopodium clavatum or Phosphorus in Wistar rats
來自巴西。探索感染克氏錐蟲的小鼠模型,以檢視高度稀釋藥物的治療:石松或磷對大鼠的影響
  
Background
  
背景
  
Associate Professor,
  
Universidade Estadual de Maringá, State of Paraná,  Brazil
  
Prof. Marques de Araújo specialising in  parasitology. Research interests include improving care for patients with  positive serology for Chagas disease and toxoplasmosis, plus ultra-diluted  medicines for the treatment of experimental infection by Trypanosoma cruzi  and Toxoplasma gondii.
  
巴西巴拉那州,馬林加大學副教授
  
Prof. Marques de Araújo專門於寄生物學。研究領域包括提高對南美錐蟲病和弓形蟲病呈陽性血清患者的治療,以超稀釋藥物對克氏錐蟲和弓形蟲之實驗性感染作治療。
  
Research area
  
研究範圍
Trypanosoma  cruzi: Biotherapy made from trypomastigote modulates the inflammatory  response. Homeopathy. January 2015
  
錐蟲:以錐蟲製成生物治療劑去調節炎症反應
  
  
Highlights
  
•Medicine made from Trypanosoma cruzi modulates the inflammatory  response.
  
•Increases apoptosis index.
  
•Decreases serum TGFβ.
  
  
亮點:
  
•以克氏錐蟲製成製成藥物去調節炎症反應。
  
•提高凋亡指數。
  
•降低血清TGFβ。
  
  
This study evaluates the effect of Trypanosoma cruzi  biotherapy 17dH (BIOT) on mice of different ages, infected with the protozoa  concerned.
  
這項研究以感染有關原生動物的不同年齡大鼠,評估「克氏錐蟲」17dH(BIOT)療劑的生物治療效用,。
  
  
Method:
  
方法:
  
Performing a blind, controlled, randomized by  drawing experiment, 110 animals four or eight-week-old, Swiss, male mice were  divided into infected control treated hydroalcoholic 7% (CI-4 = 34 or CI-8 =  21 animals) and infected control treated with biotherapy 17dH–0.2  mL/animal/20 consecutive days/oral regimen (BIOT-4 = 33 or BIOT-8 = 21  animals).以隨機抽樣執行單盲對照實驗,110  隻四週或八週齡的雄性瑞士老鼠分為兩組,一組的感染對照以7%水醇處理(水醇-四週(CI-4):34隻老鼠;水醇-八週(CI-8):21隻老鼠),另一組以生物治療劑17dH治療,每隻動物0.2毫升/ 連續20天/口服(生物治療-四週(BIOT-4):33隻老鼠;生物治療-八週(BIOT-8):21隻老鼠),處理感染對照。
  
  
Animals were inoculated intraperitoneally with 1400  trypomastigote, T. cruzi Y-strain. Parasitological, immunological and  histopathologic parameters were evaluated statistically, using Statistica-8.0  and R 3.0.2 program to analysis of survival. The study was approved by the  Ethics Committee for Animal Experimentation/UEM.
  
動物均以1400克氏錐蟲的Y株型進行腹腔接種。寄生物學、免疫學和病理學參數會使用STATISTICA-8.0和R3.0.2程式作統計評價,進行生存分析。該研究已獲得動物實驗/UEM倫理委員會批准。
  
  
Results:
  
結果:
  
Four-week-old mice showed no statistical difference  in parasitemia (P = 0.5718) between the treated and control group.  Eight-week-old mice from the treated group had a higher parasite peak (P =  0.0424) and higher parasitemia (P < 0.005) than the control.
  
4週齡老鼠中,治療組別和對照組別之間的原蟲並無顯示出統計學上差異(P = 0.5718)。八週齡老鼠中,治療組別比照組別有更高的寄生蟲峰值(P = 0.0424)和更高的寄生蟲血症(P  <0.005)。
  
  
To both groups of 4 and 8 weeks of age, treated or  untreated, survival of mice was higher in the treated group than in the  control, although it was not statistically significant (p-value = 0.32, 0.55  respectively).   
  
儘管統計數字並不顯著(p值分別= 0.32,0.55),4週齡和8週齡的兩個治療或未經治療組別中,治療組的老鼠存活率均高於對照組。
  
  
Four-week-old mice displayed a spleen section with a  number of amastigote nests significantly higher in BIOT-4 than CI-4 (P =  0.01). In eight-week-old mice the number of amastigote nests (P < 0.001)  and inflammatory foci (P < 0.06–10% significance) in the liver section  were smaller in BIOT-8 than CI-8. Spleen giant cells were significantly  higher in CI-8 than in BIOT-8 (P < 0.01).
  
4週齡老鼠的脾部,BIOT-4組別明確顯示出比CI-4(P = 0.01)組別為高的無鞭毛體巢。在八週齡老鼠,肝臟部分的無鞭毛體巢數目(P <0.001)和炎症病灶(P  <0.06-10%顯著值)在BIOT-8組別的卻比CI-8組別的較小。BIOT-8組(P <0.01)的脾巨細胞顯著高於CI-8組。
  
  
Eight-week-old animals treated with biotherapy showed  higher parasitemia and lower tissue parasitism. Opposite pattern was observed  in four-week-old animals.
  
用生物治療處理的八週齡動物,顯示出較高的寄生蟲血症和較低量組織寄生。4週齡的動物組別卻觀察到有相反的模式。
  
  
Conclusion:
  
結論:
  
There is a difference of high diluted medication  effect in four and eight-week-old mice. In the group of animals 8 weeks the  immunomodulatory effect seems to have been higher. Hence, treatment with the  medicine produced from T. cruzi modulates the inflammatory response with  increased apoptosis and decreased serum levels of TGF-β.
  
高稀釋藥物對四週齡和八週齡的老鼠有著不相同的作用。在該組中8週齡的動物似乎有較高的免疫調節作用。此外,以錐蟲製成的藥物作治療時,透過增加細胞凋亡和降低TGF-β的血清水平,可調節炎症反應。
  


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