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Dr Peter Fisher創新的順勢療法研究, 關於最新的基因表現研究

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edtps2010 發表於 2014-8-10 22:46:18 | 顯示全部樓層 |閱讀模式
<<Dr Peter Fisher | Innovative homeopathy research including latest gene expression studies
Dr Peter Fisher |創新的順勢療法研究──關於最新的基因表現研究>>


https://www.youtube.com/watch?v=-rEtiOQOdlE

Dr Peter Fisher來自皇家倫敦整全醫學醫院 (Royal London Hospital for Integrated Medicine)





也可以收看由斯特拉斯堡大學Dr Ghada Alsaleh進行的類風濕性關節炎研究,會議實況請觀看下方視頻:
http://www.hribarcelona2013.org/films.









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Yvonne 發表於 2015-9-11 02:15:28 | 顯示全部樓層
也可閱讀順勢療法療劑黃素馨(Gelsemium)於基因表現的研究
http://tinyurl.com/MarzottoGelsemium


Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-lowdoses of Gelsemiumsempervirens.
BMC Complement Altern Med. 2014 Mar 19;14:104. doi: 10.1186/1472-6882-14-104.

人類 SH-SY5Y 神經細胞的基因表現對極低劑量黃素馨(Gelsemium sempervirens) 產生極佳敏感性
Marzotto M, Olioso D, Brizzi M, Tononi P, Cristofoletti M, Bellavite P1.

http://www.biomedcentral.com/1472-6882/14/104
http://www.ncbi.nlm.nih.gov/pubm ... semium+sempervirens

Background
背景
Gelsemium sempervirens L. (Gelsemium s.) is a traditional medicinal plant, employed as an anxiolytic at ultra-low doses and animal models recently confirmed this activity. However the mechanisms by which it might operate on the nervous system are largely unknown. This work investigates the gene expression of a human neurocyte cell line treated with increasing dilutions of Gelsemium s. extract.
黃素馨(Gelsemium sempervirens L. (Gelsemium s.)) 是一種傳統的藥用植物,常以極低劑量用作一種抗焦慮劑,近年來以動物作為對象證實了這項活性。然而它對於神經系統的作用機理,仍然是所知不多。本研究將探討越來越高稀釋度的黃素馨提取物,對人類神經細胞的細胞株所產生之影響。

Methods
方法

Starting from the crude extract, six 100 × (centesimal, c) dilutions of Gelsemium s. (2c, 3c, 4c, 5c, 9c and 30c) were prepared according to the French homeopathic pharmacopoeia. Human SH-SY5Y neuroblastoma cells were exposed for 24 h to test dilutions, and their transcriptome compared by microarray to that of cells treated with control vehicle solutions.
從原物質提取物作為開始,根據法國順勢療法藥典 (French homeopathic pharmacopoeia) 記載的方法,研製出6種C(centesimal, c) 層級稀釋度的Gelsemium s.,包括2C、3C、4C、5C、9C和30C。人類 SH-SY5Y 神經母細胞瘤細胞與受測試的稀釋液接觸24小時,它們的記錄會與對照組細胞作微列陣之比較。

Results
結果
Exposure to the Gelsemium s. 2c dilution (the highest dose employed, corresponding to a gelsemine concentration of 6.5 × 10-9 M) significantly changed the expression of 56 genes, of which 49 were down-regulated and 7 were overexpressed. Several of the down-regulated genes belonged to G-protein coupled receptor signaling pathways, calcium homeostasis, inflammatory response and neuropeptide receptors. Fisher exact test, applied to the group of 49 genes down-regulated by Gelsemium s. 2c, showed that the direction of effects was significantly maintained across the treatment with high homeopathic dilutions, even though the size of the differences was distributed in a small range.
接觸Gelsemium s. 2c稀釋液(所使用的最高劑量,相當於 6.5 × 10-9 M濃度的gelsemine)的檢測,有56個基因產生表現上的顯著變化,當中有49個基因出現調降,而另外7個是增強表現的。好幾個調降基因與G蛋白偶聯受體訊息路徑、體內鈣平衡、炎症反應和神經胜肽受體有相關性。以Fisher exact test對該組49個因Gelsemium s. 2c調降的基因進行統計分析,結果顯示在使用高稀釋度順勢療法療劑的整個過程,都能維持顯著的效果,儘管當中的一些差異分布於一個細範圍之內。

Conclusions
結論
The study shows that Gelsemium s., a medicinal plant used in traditional remedies and homeopathy, modulates a series of genes involved in neuronal function. A small, but statistically significant, response was detected even to very low doses/high dilutions (up to 30c), indicating that the human neurocyte genome is extremely sensitive to this regulation.
研究指出黃素馨Gelsemium s.── 一種應用於傳統藥物和順勢療法的藥用植物,能夠調節一系列涉及神經元功能的基因。即使是非常低劑量/高稀釋度療劑(高達30c),也能被偵測到一種輕微(但在統計上顯著的)反應,指示出人類神經細胞基因組對於這種調節有極佳敏感度。
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